Grill Valdemar
Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7006 Trondheim, Norway.
Curr Diabetes Rev. 2019;15(3):174-177. doi: 10.2174/1573399814666180716150905.
Latent Autoimmune Diabetes in the Adult, LADA has been investigated less than "classical" type 1 and type 2 diabetes and the criteria for and the relevance of a LADA diagnosis have been challenged. Despite the absence of a genetic background that is exclusive for LADA this form of diabetes displays phenotypic characteristics that distinguish it from other forms of diabetes. LADA is heterogeneous in terms of the impact of autoimmunity and lifestyle factors, something that poses problems to therapy and follow-up, perhaps particularly in those with marginal positivity. Yet, there appears to be clear clinical utility in classifying individuals as LADA.
成人隐匿性自身免疫性糖尿病（LADA）的研究比“经典”1型和2型糖尿病少，LADA的诊断标准及其相关性一直受到质疑。尽管LADA没有专属的遗传背景，但这种糖尿病形式具有将其与其他糖尿病形式区分开来的表型特征。LADA在自身免疫和生活方式因素的影响方面存在异质性，这给治疗和随访带来了问题，在那些临界阳性的患者中可能尤其如此。然而，将个体分类为LADA似乎具有明确的临床实用性。
