Department of Dermatology and Venereology, Peking University First Hospital, Beijing, China.
Research Center for Medical Mycology, Peking University, Beijing, China.
Exp Dermatol. 2019 Nov;28(11):1244-1251. doi: 10.1111/exd.14020. Epub 2019 Sep 4.
Card9 is a signalling adaptor protein in the downstream of many innate pattern recognition receptors (PRRs) and exerts a significant role in antifungal immunity. To date, Card9 deficiency has been reported to be related to increased susceptibility to many fungal infections. In this study, we established mucormycosis murine model of Rhizopus arrhizus (R. arrhizus) using wild-type (WT) mice and Card9 knockout (Card9 ) mice to investigate the antifungal effect of Card9 against R. arrhizus infection. Card9 mice were more susceptible to R. arrhizus infection than WT mice, which could be related to the impaired NF-κB pathway activation, local cytokine production and Th cell responses in Card9 mice.
Card9 是许多天然模式识别受体（PRRs）下游的信号接头蛋白，在抗真菌免疫中发挥重要作用。迄今为止，Card9 缺乏已被报道与许多真菌感染的易感性增加有关。在这项研究中，我们使用野生型（WT）小鼠和 Card9 敲除（Card9 -/-）小鼠建立了根霉（Rhizopus arrhizus）毛霉病小鼠模型，以研究 Card9 对 R. arrhizus 感染的抗真菌作用。Card9 -/- 小鼠比 WT 小鼠更容易感染 R. arrhizus，这可能与 Card9 -/- 小鼠中 NF-κB 途径激活、局部细胞因子产生和 Th 细胞反应受损有关。
