三氟甲磺酸酐促进的 3,4-二氢喹唑啉合成：一种三组分一锅串联反应。
Triflic anhydride mediated synthesis of 3,4-dihydroquinazolines: a three-component one-pot tandem procedure.
机构信息
Department of Chemistry, Lake Superior State University, Sault Sainte Marie, MI 49783, USA.
出版信息
Org Biomol Chem. 2019 Aug 28;17(34):7995-8000. doi: 10.1039/c9ob01596e.
Abstract
A one-pot three-component tandem reaction involving a key Pictet-Spengler-like annulation step has been developed, providing an efficient method for the synthesis of 3,4-dihydroquinazolines in moderate to good yields from amides, aldehydes, and amines. The multicomponent triflic anhydride mediated reaction tolerates the installation of numerous functional groups, affording extensive diversity about the heterocyclic scaffold.
摘要
发展了一种涉及关键 Pictet-Spengler 型环合步骤的一锅法三组分串联反应，为酰胺、醛和胺合成 3,4-二氢喹唑啉提供了一种从中等到良好收率的有效方法。多组分三氟甲磺酸酐介导的反应能够容忍众多官能团的安装，为杂环支架提供了广泛的多样性。
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