伯酰胺和仲酰胺的通用及选择性双膦酰化反应。
General and chemoselective bisphosphonylation of secondary and tertiary amides.
机构信息
Department of Chemistry, Fujian Provincial Key Laboratory of Chemical Biology, College of Chemistry and Chemical Engineering, and Collaborative Innovation Centre of Chemistry for Energy Materials, Xiamen University , Xiamen, Fujian 361005, P. R. China.
出版信息
Org Lett. 2015 Feb 6;17(3):732-5. doi: 10.1021/acs.orglett.5b00004. Epub 2015 Jan 27.
PMID:25625596
Abstract
With Tf2O as the activation reagent, a mild and general method has been developed for the bisphosphonylation of both secondary and tertiary amides. The protocol is highly efficient and chemoselective, and it tolerates a number of sensitive functional groups such as cyano, ester, and aldehyde groups.
摘要
以 Tf2O 作为活化试剂，我们开发出了一种温和且通用的方法，可实现仲酰胺和叔酰胺的双膦酰化反应。该方法具有高效和化学选择性，且能够容忍许多敏感的官能团，如氰基、酯基和醛基。
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