Department of Chemistry, Fujian Provincial Key Laboratory of Chemical Biology, College of Chemistry and Chemical Engineering, and Collaborative Innovation Centre of Chemistry for Energy Materials, Xiamen University , Xiamen, Fujian 361005, P. R. China.
Org Lett. 2015 Feb 6;17(3):732-5. doi: 10.1021/acs.orglett.5b00004. Epub 2015 Jan 27.
With Tf2O as the activation reagent, a mild and general method has been developed for the bisphosphonylation of both secondary and tertiary amides. The protocol is highly efficient and chemoselective, and it tolerates a number of sensitive functional groups such as cyano, ester, and aldehyde groups.
以 Tf2O 作为活化试剂，我们开发出了一种温和且通用的方法，可实现仲酰胺和叔酰胺的双膦酰化反应。该方法具有高效和化学选择性，且能够容忍许多敏感的官能团，如氰基、酯基和醛基。
