成人神经发生在癫痫发展中的作用
Adult Neurogenesis in the Development of Epilepsy.
作者信息
Danzer Steve C
机构信息
Department of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Department of Anesthesia, University of Cincinnati, Cincinnati, OH, USA.
出版信息
Epilepsy Curr. 2019 Sep;19(5):316-320. doi: 10.1177/1535759719868186. Epub 2019 Aug 13.
Abstract
Compelling evidence indicates that hippocampal dentate granule cells are generated throughout human life and into old age. While animal studies demonstrate that these new neurons are important for memory function, animal research also implicates these cells in the pathogenesis of temporal lobe epilepsy. Several recent preclinical studies in rodents now suggest that targeting these new neurons can have disease-modifying effects in epilepsy.
摘要
有力证据表明，海马齿状颗粒细胞在人类一生中持续产生，直至老年。虽然动物研究表明这些新神经元对记忆功能很重要，但动物研究也表明这些细胞与颞叶癫痫的发病机制有关。最近几项针对啮齿动物的临床前研究表明，针对这些新神经元可能对癫痫具有疾病修饰作用。
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本文引用的文献
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Adult neurogenesis in the mouse dentate gyrus protects the hippocampus from neuronal injury following severe seizures.成年小鼠齿状回神经发生可保护海马神经元免受严重癫痫发作后的损伤。
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