Sehgal L R, Sehgal H L, Rosen A L, Gould S A, DeWoskin R, Moss G S
Department of Surgery, Michael Reese Hospital & Medical Center, University of Chicago Pritzker School of Medicine, Illinois 60616.
Biomater Artif Cells Artif Organs. 1988;16(1-3):173-83. doi: 10.3109/10731198809132567.
Polymerization of SFH-P currently provides the only approach that leads to a hemoglobin solution that approximates the O2 carrying capacity of whole blood and can be infused without altering the COP of plasma. It appears to have an adequate O2 loading and unloading characteristic and a greatly improved intravascular half-life. In addition, stable shelf-life at 4 degrees C of greater than five months, makes it a prime candidate for future pre-clinical and clinical investigations.
目前，SFH-P的聚合作用是唯一能产生接近全血携氧能力的血红蛋白溶液且输注时不会改变血浆胶体渗透压的方法。它似乎具有足够的氧加载和卸载特性，并且血管内半衰期有了极大改善。此外，在4摄氏度下大于五个月的稳定保质期使其成为未来临床前和临床研究的主要候选对象。
