Mishra Amit Kumar, Mehra Ketan, Manikandan Ramanitharan, Dorairajan Lalgudi Narayanan
Department of Urology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
BMJ Case Rep. 2019 Aug 12;12(8):e230826. doi: 10.1136/bcr-2019-230826.
Leukemoid reaction is a paraneoplastic phenomenon associated predominantly with solid tumours. Malignancies presenting with leukemoid reaction have a grave prognosis. It is defined as persistent neutrophil count greater than 50×103 cells/µL. We report a case of leukemoid reaction in a patient with metastatic penile cancer. A 60-year-old man with partial penectomy status for squamous cell carcinoma of penis on neoadjuvant chemotherapy, presented with left fungating inguinal lymphadenopathy and total leucocyte count 96×103 cells/µL and hypercalcaemia. Leucocytealkaline phosphatase (LAP) score was excessively elevated. The patient underwent left ilioinguinal block dissection along with vastus lateralis flap for defect reconstruction. Postoperatively, the neutrophil counts and serum calcium level normalised. The patient improved clinically and was discharged.
类白血病反应是一种主要与实体瘤相关的副肿瘤现象。出现类白血病反应的恶性肿瘤预后严重。它被定义为持续性中性粒细胞计数大于50×10³个细胞/微升。我们报告一例转移性阴茎癌患者发生类白血病反应的病例。一名60岁男性，因阴茎鳞状细胞癌接受新辅助化疗后行部分阴茎切除术，出现左侧溃疡性腹股沟淋巴结肿大，全白细胞计数为96×10³个细胞/微升，并有高钙血症。白细胞碱性磷酸酶（LAP）评分显著升高。患者接受了左髂腹股沟淋巴结清扫术，并采用股外侧肌皮瓣进行缺损重建。术后，中性粒细胞计数和血清钙水平恢复正常。患者临床症状改善并出院。
