McKee L C
South Med J. 1985 Dec;78(12):1475-82. doi: 10.1097/00007611-198512000-00018.
Twenty-one patients with malignancy had a peripheral white blood cell count of 50,000/cu mm or more. The malignancies arose from several tissues, especially lung; all were carcinomas except for one osteogenic sarcoma. In no case was there evidence of leukemia as defined by disorderly marrow growth, abnormal chromosomes, or abnormal leukocyte alkaline phosphatase levels. The peripheral blood of these patients showed segmented neutrophils, bands, and occasional metamyelocytes. When young cells such as myelocytes were seen, they did not persist. A high WBC with malignancy is a late phenomenon, usually occurring shortly before death, and does not correlate with any pathologic findings such as necrosis, white cell infiltration of the tumor, or specific inflammatory changes. most of the associated tumors are of giant cell size, but serum showed no evidence of colony stimulating activity. This was true of two tumors reported in the literature, yet the tumors could be shown in vitro to produce colony stimulating activity. The tumor probably does produce some type of granulocytopoietin, but methods for detecting it are presently limited.
21例恶性肿瘤患者的外周血白细胞计数达到或超过50,000/立方毫米。这些恶性肿瘤起源于多个组织，尤其是肺；除1例骨肉瘤外，均为癌。在任何病例中，均无骨髓生长紊乱、染色体异常或白细胞碱性磷酸酶水平异常所定义的白血病证据。这些患者的外周血显示有分叶核中性粒细胞、杆状核粒细胞，偶尔还有晚幼粒细胞。当见到如中幼粒细胞等幼稚细胞时，它们不会持续存在。恶性肿瘤患者白细胞计数升高是一种晚期现象，通常在死亡前不久出现，且与任何病理表现如坏死、肿瘤白细胞浸润或特定炎症变化均无关联。大多数相关肿瘤为巨细胞大小，但血清未显示集落刺激活性的证据。文献报道的两个肿瘤也是如此，然而这些肿瘤在体外可显示产生集落刺激活性。肿瘤可能确实产生某种类型的粒细胞生成素，但目前检测它方法有限。
