补体系统与年龄相关性黄斑变性：药物与挑战
Complement system and age-related macular degeneration: drugs and challenges.
作者信息
Wu Jiali, Sun Xiaodong
机构信息
Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Shanghai Key Laboratory of Fundus Disease, Shanghai, People's Republic of China.
出版信息
Drug Des Devel Ther. 2019 Jul 19;13:2413-2425. doi: 10.2147/DDDT.S206355. eCollection 2019.
Age-related macular degeneration (AMD) is directly attributable to vision loss, posing significant pressure on public health. AMD is recognized to be a multi-factorial disease and among them, complement system is under heated discussion in recent years. In this review, we start with an overview of complement pathways involved in AMD and their therapies correspondingly. Finally, we discuss the development of the therapeutics existed now. Also, we enclose a list of drugs undergoing clinical trials.
年龄相关性黄斑变性（AMD）直接导致视力丧失，给公共卫生带来巨大压力。AMD被认为是一种多因素疾病，其中补体系统是近年来讨论的热点。在本综述中，我们首先概述了参与AMD的补体途径及其相应的治疗方法。最后，我们讨论了现有治疗方法的发展情况。此外，我们附上了一份正在进行临床试验的药物清单。
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