核孔复合体蓝图的探索。
The Quest for the Blueprint of the Nuclear Pore Complex.
机构信息
Fisch College of Pharmacy, University of Texas at Tyler, Tyler, TX, 75799, USA.
出版信息
Protein J. 2019 Aug;38(4):363-376. doi: 10.1007/s10930-019-09858-z.
During my postdoc interview in June of 1998, I asked Günter why he was moving more towards the nucleus in his latest studies. He said, "Well Joe, that's where everything starts." By the end of the interview, I accepted the postdoc. He had a way of making everything sound so cool. Günter's progression was natural, since the endoplasmic reticulum and the nucleus are the only organelles that share the same membrane. The nuclear envelope extends into a double membrane system with nuclear pore complexes embedded in the pore membrane openings. Even while writing this review, I remember Günter stressing; it is the nuclear pore complex. Just saying nuclear pore doesn't encompass the full magnitude of its significance. The nuclear pore complex is one of the largest collection of proteins that fit together for an overall function: transport. This review will cover the Blobel lab contributions in the quest for the blueprint of the nuclear pore complex from isolation of the nuclear envelope and nuclear lamin to the ring structures.
在 1998 年 6 月的博士后面试中，我问 Günter 为什么他在最近的研究中更多地转向细胞核。他说：“乔，一切都从那里开始。”面试结束时，我接受了这个博士后职位。他有一种让一切听起来都很酷的方式。Günter 的进展是自然而然的，因为内质网和细胞核是唯一具有相同膜的细胞器。核膜延伸为一个双膜系统，核孔复合物嵌入在孔膜开口中。即使在写这篇综述时，我还记得 Günter 强调过；是核孔复合物。仅仅说核孔并不能涵盖其全部意义。核孔复合物是最大的蛋白质集合之一，它们共同发挥整体功能：运输。这篇综述将涵盖 Blobel 实验室在从核膜和核纤层的分离到环结构的核孔复合物蓝图探索方面的贡献。
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