血清和尿液中氟罗沙星的液相色谱测定法
Liquid-chromatographic determination of fleroxacin in serum and urine.
作者信息
Awni W M, Maloney J A, Heim-Duthoy K L
机构信息
College of Pharmacy, University of Minnesota, Minneapolis.
出版信息
Clin Chem. 1988 Nov;34(11):2330-2.
PMID:3141086
Abstract
This highly sensitive, accurate, and reproducible HPLC method for determining fleroxacin in human serum and urine makes use of a common C18 column, a fluorescence detector, and an internal standard. Serum samples require a simple extraction procedure; urine must be diluted. The method, which we have used extensively for pharmacokinetic assessment of fleroxacin in patients, measures concentrations as low as 5 micrograms/L.
摘要
这种用于测定人血清和尿液中氟罗沙星的高效液相色谱法灵敏度高、准确性好且可重复性强，它使用普通的C18柱、荧光检测器和内标。血清样本需要简单的提取程序；尿液必须稀释。我们已广泛将该方法用于患者氟罗沙星的药代动力学评估，其可测量低至5微克/升的浓度。
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