具有卟啉壳的用于癌症治疗与诊断的纳米乳剂。
A Nanoemulsion with A Porphyrin Shell for Cancer Theranostics.
机构信息
Princess Margaret Cancer Centre, University Health Network, 101 College St., PMCRT 5-354, Toronto, ON, Canada.
Department of Instrument Science and Engineering, Shanghai Jiao Tong University, Shanghai, China.
出版信息
Angew Chem Int Ed Engl. 2019 Oct 14;58(42):14974-14978. doi: 10.1002/anie.201908664. Epub 2019 Sep 5.
A nanoemulsion with a porphyrin shell (NewPS) was created by the self-assembly of porphyrin salt around an oil core. The NewPS system has excellent colloidal stability, is amenable to different porphyrin salts and oils, and is capable of co-loading with chemotherapeutics. The porphyrin salt shell enables porphyrin-dependent optical tunability. The NewPS consisting of pyropheophorbide a mono-salt has a porphyrin shell of ordered J-aggregates, which produced a narrow, red-shifted Q-band with increased absorbance. Upon nanostructure dissociation, the fluorescence and photodynamic reactivity of the porphyrin monomers are restored. The spectrally distinct photoacoustic imaging (at 715 nm by intact NewPS) and fluorescence increase (at 671 nm by disrupted NewPS) allow the monitoring of NewPS accumulation and disruption in mice bearing KB tumors to guide effective photodynamic therapy. Substituting the oil core with Lipiodol affords additional CT contrast, whereas loading paclitaxel into NewPS facilitates drug delivery.
一种具有卟啉壳的纳米乳剂（NewPS）是通过卟啉盐在油核周围自组装形成的。NewPS 体系具有优异的胶体稳定性，适用于不同的卟啉盐和油，并能够与化疗药物共同负载。卟啉盐壳使卟啉具有依赖于光的可调谐性。由焦脱镁叶绿酸 a 单盐组成的 NewPS 具有有序 J-聚集的卟啉壳，产生了窄的、红移的 Q 带，吸收增加。纳米结构解离后，卟啉单体的荧光和光动力反应性得到恢复。光谱上明显的光声成像（完整的 NewPS 在 715nm 处）和荧光增强（破坏的 NewPS 在 671nm 处）允许监测携带 KB 肿瘤的小鼠中 NewPS 的积累和破坏，以指导有效的光动力治疗。用 Lipiodol 替代油核可提供额外的 CT 对比，而将紫杉醇载入 NewPS 则有利于药物递送。
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