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一种靶向线粒体的铱(III)基光酸产生剂在癌细胞内诱导双重模式的光动力损伤。

A mitochondria-targeted iridium(iii)-based photoacid generator induces dual-mode photodynamic damage within cancer cells.

机构信息

Department of Applied Chemistry, College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China.

出版信息

Chem Commun (Camb). 2019 Aug 27;55(70):10472-10475. doi: 10.1039/c9cc04871e.

DOI:10.1039/c9cc04871e
PMID:31411208
Abstract

A mitochondria-targeted photodynamic therapy (PDT) agent was designed and synthesized. Upon light irradiation, it can produce photoacid and its photolysis products can further sensitize 1O2 generation, causing dual-mode (oxygen-independent and oxygen-dependent) photodynamic damage in mitochondria and killing cancer cells effectively even under hypoxic conditions.

摘要

设计并合成了一种靶向线粒体的光动力治疗（PDT）试剂。在光照下，它可以产生光酸，其光解产物可以进一步敏化 1O2 的生成，从而在缺氧条件下有效导致线粒体的双重模式（非依赖氧和依赖氧）光动力损伤并杀死癌细胞。

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