Department of General Surgery, GongLi Hospital of Shanghai Pu Dong New District, Shanghai, 200135, China.
Department of Ultrasound, GongLi Hospital of Shanghai Pu Dong New District, Shanghai, 200135, China.
Clinics (Sao Paulo). 2019;74:e729. doi: 10.6061/clinics/2019/e729. Epub 2019 Aug 12.
To investigate the relationship between the serum levels of NLRP3 and HMGB-1 and the prognosis of patients with severe blunt abdominal trauma.
In total, 299 patients were included in the current study from July 2014 to December 2015. All patients were divided into the mild/moderate blunt abdominal trauma group and the severe blunt abdominal trauma group according to their injury severity scores. Serum levels of NLRP3 and HMGB-1 were measured upon admission (0 h) and at 12 h, 24 h, 48 h, 72 h and 7 days after admission.
Compared with the healthy controls, both the mild/moderate and severe blunt abdominal trauma groups had higher serum levels of NLRP3 and HMGB-1 at admission. At all points, the serum levels of NLRP3 and HMGB-1 were significantly higher in the severe group than in the mild/moderate group. The serum levels of both NLRP3 and HMGB-1 were significantly higher in the deceased patients than in the living patients. The Kaplan-Meier curve showed that compared with patients with higher levels of NLRP3 or HMGB-1, those with lower levels had longer survival times. The serum levels of both NLRP3 and HMGB-1 were independent risk factors for 6-month mortality in severe blunt abdominal trauma patients.
The serum levels of NLRP3 and HMGB-1 were significantly elevated in severe blunt abdominal trauma patients, and the serum levels of both NLRP3 and HMGB-1 were correlated with 6-month mortality in severe blunt abdominal trauma patients.
探讨血清 NLRP3 和 HMGB-1 水平与严重钝性腹部创伤患者预后的关系。
本研究共纳入 2014 年 7 月至 2015 年 12 月期间的 299 例患者。所有患者根据损伤严重程度评分分为轻度/中度钝性腹部创伤组和严重钝性腹部创伤组。入院时（0 h）及入院后 12 h、24 h、48 h、72 h 和 7 天，测定血清 NLRP3 和 HMGB-1 水平。
与健康对照组相比，入院时轻度/中度和严重钝性腹部创伤组患者血清 NLRP3 和 HMGB-1 水平均升高。在所有时间点，严重组患者血清 NLRP3 和 HMGB-1 水平均显著高于轻度/中度组。死亡患者血清 NLRP3 和 HMGB-1 水平均显著高于存活患者。Kaplan-Meier 曲线显示，与 NLRP3 或 HMGB-1 水平较高的患者相比，水平较低的患者生存时间更长。血清 NLRP3 和 HMGB-1 水平是严重钝性腹部创伤患者 6 个月死亡率的独立危险因素。
严重钝性腹部创伤患者血清 NLRP3 和 HMGB-1 水平显著升高，且血清 NLRP3 和 HMGB-1 水平与严重钝性腹部创伤患者 6 个月死亡率相关。
