ACS Appl Mater Interfaces. 2019 Sep 11;11(36):32659-32669. doi: 10.1021/acsami.9b09824. Epub 2019 Aug 27.
The development of new antibacterial agents to deal with the emergence and spread of antibiotic resistance in Gram-positive bacterial pathogens has become an increasing problem. Here, a new strategy is developed for the effective targeting and killing of Gram-positive bacteria based on vancomycin (Van)-modified gold nanostars (AuNSs). Our work has demonstrated that the Van-modified AuNSs (AuNSs@Van) can not only selectively recognize methicillin-resistant MRSA) but also kill MRSA under near-infrared laser irradiation in vitro. Additionally, AuNSs@Van shows satisfactory biocompatibility and antibacterial activity in treating bacterial infection in vivo. The attractive trait of AuNSs@Van is attributed to the physical effect of its antibacterial activity, with less potential for resistance development. The aforementioned advantages indicate the potential of AuNSs@Van as a photothermal antibacterial agent for effectively combating Gram-positive bacteria in the field of health care.
针对革兰氏阳性菌病原体中抗生素耐药性的出现和传播，开发新的抗菌剂已成为一个日益严重的问题。在这里，我们基于万古霉素（Van）修饰的金纳米星（AuNSs）开发了一种针对革兰氏阳性菌的有效靶向和杀伤的新策略。我们的工作表明，Van 修饰的 AuNSs（AuNSs@Van）不仅可以选择性地识别耐甲氧西林金黄色葡萄球菌（MRSA），而且可以在近红外激光照射下在体外杀死 MRSA。此外，AuNSs@Van 在体内治疗细菌感染时表现出令人满意的生物相容性和抗菌活性。AuNSs@Van 的吸引力在于其抗菌活性的物理效应，其发展出耐药性的潜力较小。上述优点表明，AuNSs@Van 作为一种光热抗菌剂，有望在医疗保健领域有效对抗革兰氏阳性菌。
