Pammi S V N, Alipour Amir Mohammad, Matangi Ravichandra, Gurugubelli Thirumala Rao, Perumalveeramalai Chandrasekar, Ruddaraju Lakshmi Kalyani
School of Technology, Woxsen University, Hyderabad, Telangana 502345, India.
Sri Venkateswara College of Pharmacy, Etcherla, Srikakulam 532410, India.
iScience. 2025 Apr 23;28(6):112518. doi: 10.1016/j.isci.2025.112518. eCollection 2025 Jun 20.
The discovery of antibiotics in the 20th century has played a crucial role in contemporary medicine for treating bacterial infections; however, the rise of antimicrobial resistance poses a significant threat to their efficacy, creating a global health crisis. On the other hand, the lack of discovery of new antibiotics for overcoming resistance has stagnated. In this context, metallic nanoparticles (MNPs) prepared with green approaches (P-MNPs) have emerged as viable options for combating multidrug-resistant bacteria and inhibiting biofilm formation. Additionally, when combined with commercial antibiotics, P-MNPs enhance drug delivery, improve circulation, and effectively target bacteria, reducing the required dosage and expanding antibacterial activity while maintaining biocompatibility. In this review, synergistic antibacterial mechanisms of P-MNPs and antibiotics (nAbts), their wound healing and cytotoxicity studies are underscored, which paves a road map for the researchers and medical practitioners to use nAbts in clinical translations.
20世纪抗生素的发现对当代医学治疗细菌感染起到了关键作用；然而，抗菌药物耐药性的出现对其疗效构成了重大威胁，引发了全球健康危机。另一方面，用于克服耐药性的新型抗生素的发现停滞不前。在此背景下，采用绿色方法制备的金属纳米颗粒（P-MNPs）已成为对抗多重耐药细菌和抑制生物膜形成的可行选择。此外，当与商业抗生素联合使用时，P-MNPs可增强药物递送、改善循环并有效靶向细菌，减少所需剂量并扩大抗菌活性，同时保持生物相容性。在本综述中，强调了P-MNPs与抗生素（nAbts）的协同抗菌机制、它们的伤口愈合和细胞毒性研究，这为研究人员和医学从业者在临床转化中使用nAbts铺平了道路。
