Beckers Laura W M E, Stal Rosalinde A, Smeets Rob J E M, Onghena Patrick, Bastiaenen Caroline H G
Department of Rehabilitation Medicine, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, Netherlands.
Centre of Expertise in Rehabilitation and Audiology, Adelante, Hoensbroek, Netherlands.
Dev Neurorehabil. 2020 Feb;23(2):73-105. doi: 10.1080/17518423.2019.1645226. Epub 2019 Aug 14.
: To critically evaluate single-case design (SCD) studies performed within the population of children/adolescents with cerebral palsy (CP).: A scoping review of SCD studies of children/adolescents with CP. Demographic, methodological, and statistical data were extracted. Articles were evaluated using the Risk of Bias in N-of-1 Trials (RoBiNT) Scale and the Consolidated Standards of Reporting Trials (CONSORT) extension for N-of-1 trials (CENT 2015). Comments regarding strengths and limitations were analyzed.: Studies investigated the effects of a wide range of interventions on various outcomes. Most SCD types were adopted in multiple studies. All studies used visual inspection rather than visual analysis, often complemented with basic statistical descriptives. Risk of bias was high, particularly concerning internal validity. Many CENT items were insufficiently reported. Several benefits and limitations of SCD were identified.: The quality of evidence from results of SCD studies needs to be increased through risk of bias reduction.
批判性评估针对脑瘫（CP）儿童/青少年群体开展的单病例设计（SCD）研究。对CP儿童/青少年的SCD研究进行范围综述。提取人口统计学、方法学和统计数据。使用单病例试验偏倚风险（RoBiNT）量表和单病例试验报告统一标准（CONSORT）扩展版（CENT 2015）对文章进行评估。分析关于优势和局限性的评论。研究调查了多种干预措施对各种结局的影响。多数SCD类型在多项研究中被采用。所有研究都使用了直观检查而非直观分析，且常辅以基本统计描述。偏倚风险较高，尤其是在内部效度方面。许多CENT条目报告不足。确定了SCD的若干益处和局限性。需通过降低偏倚风险来提高SCD研究结果的证据质量。
