Nahidi Yalda, Delghandi Seyedeh Rozita, Kiafar Bita, Saki Azadeh
Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Resident of Dermatology, Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
J Dermatolog Treat. 2021 May;32(3):340-344. doi: 10.1080/09546634.2019.1655136. Epub 2019 Aug 29.
This aim of this study was to determine the effect of 1540-nm nonablative fractional erbium on macular amyloidosis.
This phase-II clinical trial study has been performed with parallel group with blinding of the evaluator. The skin lesions of the patients (15 patients and 30 lesions) with cutaneous macular amyloidosis were randomly assigned into laser and no-treatment groups. In the laser group, treatment was performed by 1540-nm nonablative fractional erbium laser. Thereafter, the patients' lesions were compared in terms of pigmentation, rippling, thickness, and subjective response.
The lesions of the intervention group significantly improved in the three-month follow-up compared to the control group (in the control and intervention group, improved pigmentation was observed in 20 and 53.3% with = .02, improved rippling in 6.7 and 60% with = .007, diminished lichenification in 0 and 53.1% with = .007, and overall lesion improvement in 20 and 60% with = .03, respectively). In investigating the subjective response through patient global assessment, the patients in the intervention group had a greater satisfaction ( = .01). There was a considerable improvement of pruritus in the intervention group ( = .001).
Use of 1540-nm nonablative fractional erbium laser offered a suitable efficacy to treat macular amyloidosis without significant complications.
本研究旨在确定1540纳米非剥脱性铒激光对黄斑淀粉样变的疗效。
本II期临床试验采用平行组设计，评估者设盲。将15例皮肤黄斑淀粉样变患者的30处皮肤病变随机分为激光治疗组和非治疗组。激光治疗组采用1540纳米非剥脱性铒激光进行治疗。此后，对患者病变的色素沉着、波纹、厚度和主观反应进行比较。
与对照组相比，干预组的病变在三个月随访中显著改善（对照组和干预组中，色素沉着改善分别为20%和53.3%，P = 0.02；波纹改善分别为6.7%和60%，P = 0.007；苔藓化减轻分别为0和53.1%，P = 0.007；总体病变改善分别为20%和60%，P = 0.03）。通过患者整体评估调查主观反应时，干预组患者的满意度更高（P = 0.01）。干预组的瘙痒症状有显著改善（P = 0.001）。
使用1540纳米非剥脱性铒激光治疗黄斑淀粉样变疗效良好，且无明显并发症。
