帕金森病患者认知、情绪与纹状体多巴胺能结合的纵向关联。
The longitudinal associations between cognition, mood and striatal dopaminergic binding in Parkinson's Disease.
机构信息
Department of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Lou Ruvo Center for Brain Health, Cleveland Clinic, Las Vegas, NV, USA.
出版信息
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2020 Jul;27(4):581-594. doi: 10.1080/13825585.2019.1653445. Epub 2019 Aug 14.
Abstract
Cognitive decline and mood symptoms are common in Parkinson's disease (PD). Reductions in striatal dopaminergic binding have been associated with worse cognition and mood. We investigated whether this association persists throughout the disease progression in newly diagnosed PD. Four-year data from Parkinson's Progression Markers Initiative (PPMI) were used. Groups consisted of left and right limb dominantly affected PD patients, and controls. Longitudinal relationships between cognition, mood and striatal binding ratios were assessed by repeated measures correlations. Reduced binding was associated with general cognitive decline in controls, reduced processing speed and increased mood symptoms in PD. Anxiety was associated with striatum only in left limb dominantly affected PD. Dominantly affected limb side did not impact striatum and cognition association. There are longitudinal associations between striatum, processing speed and anxiety. Dopamine transporter availability imaging may have some prognostic value for cognition and mood in PD.
摘要
认知衰退和情绪症状在帕金森病（PD）中很常见。纹状体多巴胺能结合的减少与认知和情绪的恶化有关。我们研究了这种关联是否在新诊断的 PD 疾病进展过程中仍然存在。使用了帕金森病进展标志物倡议（PPMI）的四年数据。组由左、右肢体优势影响的 PD 患者和对照组组成。通过重复测量相关性评估认知、情绪和纹状体结合率之间的纵向关系。结合减少与对照组的一般认知下降、处理速度降低和情绪症状增加有关。在左侧肢体优势影响的 PD 中，焦虑与纹状体有关。优势肢体侧不影响纹状体和认知的关联。纹状体、处理速度和焦虑之间存在纵向关联。多巴胺转运蛋白可用性成像可能对 PD 的认知和情绪具有一定的预后价值。
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