Department of Interventional Ultrasound, Chinese PLA General Hospital, Beijing 100853, PR China.
Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, PR China.
Nanomedicine (Lond). 2019 Aug;14(16):2151-2167. doi: 10.2217/nnm-2018-0424. Epub 2019 Aug 14.
This study aimed to develop indocyanine green- and doxorubicin-loaded liposomes (DILPs) as theranostic nanoplatform for the detection of hepatocellular carcinoma (HCC) and as an efficient chemotherapeutic to enhance microwave ablation. DILPs were synthesized and thoroughly characterized. Biocompatibility, tumor uptake and accumulation, and synergistic ablation-chemotherapeutic efficiency were systematically explored in them. In addition, human HCC surgical samples were used to test the affinity of DILPs for HCC. The combination of microwave ablation and DILPs enhanced the ablation efficiency of HCC with apparent tumor inhibition. DILPs exhibited excellent diagnostic ability and could detect 2.5-mm HCC lesions via optoacoustic tomography imaging. DILPs had better affinity for human HCC surgical samples compared with normal liver tissue. Theranostic DILPs could serve as promising nanoparticles for treatment and management of HCC in the clinic.
本研究旨在开发载有吲哚菁绿和阿霉素的脂质体（DILPs）作为用于检测肝细胞癌（HCC）的治疗诊断纳米平台，以及作为一种有效的化疗药物来增强微波消融效果。合成并对 DILPs 进行了全面表征。系统地研究了它们的生物相容性、肿瘤摄取和积累，以及协同消融-化疗效率。此外，还使用人 HCC 手术样本测试了 DILPs 对 HCC 的亲和力。微波消融联合 DILPs 增强了 HCC 的消融效率，明显抑制了肿瘤生长。DILPs 表现出优异的诊断能力，可通过光声断层扫描成像检测 2.5mm 的 HCC 病变。与正常肝组织相比，DILPs 对人 HCC 手术样本具有更好的亲和力。治疗诊断 DILPs 有望成为临床治疗和管理 HCC 的一种有前途的纳米颗粒。
