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纳米脂质体在肝癌诊断和治疗中的研究进展。

Advances in Nanoliposomes for the Diagnosis and Treatment of Liver Cancer.

机构信息

NHC Key Laboratory of Radiobiology (Jilin University), School of Public Health, Jilin University, Changchun, 130021, Jilin, People's Republic of China.

Second Clinical Medical College, Henan University of Traditional Chinese Medicine, Zhengzhou, 450052, Henan, People's Republic of China.

出版信息

Int J Nanomedicine. 2022 Feb 26;17:909-925. doi: 10.2147/IJN.S349426. eCollection 2022.

Abstract

The mortality rate of liver cancer is gradually increasing worldwide due to the increasing risk factors such as fatty liver, diabetes, and alcoholic cirrhosis. The diagnostic methods of liver cancer include ultrasound (US), computed tomography (CT), and magnetic resonance imaging (MRI), among others. The treatment of liver cancer includes surgical resection, transplantation, ablation, and chemoembolization; however, treatment still faces multiple challenges due to its insidious development, high rate of recurrence after surgical resection, and high failure rate of transplantation. The emergence of liposomes has provided new insights into the treatment of liver cancer. Due to their excellent carrier properties and maneuverability, liposomes can be used to perform a variety of functions such as aiding in imaging diagnoses, combinatorial therapies, and integrating disease diagnosis and treatment. In this paper, we further discuss such advantages.

摘要

由于脂肪肝、糖尿病和酒精性肝硬化等危险因素的增加,全球肝癌的死亡率逐渐上升。肝癌的诊断方法包括超声(US)、计算机断层扫描(CT)和磁共振成像(MRI)等。肝癌的治疗方法包括手术切除、移植、消融和化疗栓塞;然而,由于其隐匿性发展、手术后复发率高和移植失败率高,治疗仍然面临多重挑战。脂质体的出现为肝癌的治疗提供了新的思路。由于其优异的载体性能和可操作性,脂质体可以用于执行多种功能,如辅助成像诊断、联合治疗以及整合疾病诊断和治疗。在本文中,我们将进一步讨论这些优势。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/230d/8893038/d9a6df79305b/IJN-17-909-g0001.jpg

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