手性亚砜的酶动力学拆分——一种对映互补的方法。
Enzymatic kinetic resolution of chiral sulfoxides - an enantiocomplementary approach.
机构信息
Department of Organic Chemistry, Faculty of Science, Charles University in Prague Hlavova 2030/8, 12843 Prague 2, Czech Republic.
出版信息
Chem Commun (Camb). 2019 Aug 27;55(70):10480-10483. doi: 10.1039/c9cc05470g.
PMID:31411608
Abstract
A new enzymatic assay for the preparation of chiral sulfoxides that is enantiocomplementary to the known (S)-enantiomer-reducing activity of methionine sulfoxide reductase A (MsrA) is described. To this end, we have utilized the enzyme DMSO reductase (DmsABC), recently discovered by us being highly upregulated in stationary phase E. coli bacteria.
摘要
描述了一种新的酶促分析方法，用于制备手性亚砜，该方法与已知的甲硫氨酸亚砜还原酶 A（MsrA）的（S）-对映异构体还原活性互补。为此，我们利用了最近由我们发现的在大肠杆菌的静止期高度上调的二甲基亚砜还原酶（DmsABC）。
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