Ragon Institute of MGH, MIT and Harvard, Cambridge MA 02139 and The MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
Dana-Farber Cancer Institute, Pediatric Oncology, Harvard Medical School, Boston, MA 02115, USA.
Glycobiology. 2019 Nov 20;29(12):861-875. doi: 10.1093/glycob/cwz062.
The origins of plasmacytoid dendritic cells (pDCs) have long been controversial and progenitors exclusively committed to this lineage have not been described. We show here that the fate of hematopoietic progenitors is determined in part by their surface levels of 9-O-acetyl sialic acid. Pro-pDCs were identified as lineage negative 9-O-acetyl sialic acid low progenitors that lack myeloid and lymphoid potential but differentiate into pre-pDCs. The latter cells are also lineage negative, 9-O-acetyl sialic acid low cells but are exclusively committed to the pDC lineage. Levels of 9-O-acetyl sialic acid provide a distinct way to define progenitors and thus facilitate the study of hematopoietic differentiation.
浆细胞样树突状细胞（pDC）的起源一直存在争议，并且尚未描述专门用于此谱系的祖细胞。我们在这里表明，造血祖细胞的命运部分取决于其表面 9-O-乙酰神经氨酸的水平。前 pDC 被鉴定为谱系阴性 9-O-乙酰神经氨酸低祖细胞，缺乏髓样和淋巴样潜能，但分化为前 pDC。后一种细胞也是谱系阴性，9-O-乙酰神经氨酸低细胞，但专门用于 pDC 谱系。9-O-乙酰神经氨酸的水平为定义祖细胞提供了一种独特的方法，从而促进了造血分化的研究。
