小鼠浆细胞样树突状细胞仅来源于雌激素抵抗性髓系祖细胞。
Mouse plasmacytoid dendritic cells derive exclusively from estrogen-resistant myeloid progenitors.
作者信息
Harman Benjamin C, Miller Juli P, Nikbakht Neda, Gerstein Rachel, Allman David
机构信息
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 36th and Hamilton Walk, 230 John Morgan Bldg, Philadelphia, 19104, USA.
出版信息
Blood. 2006 Aug 1;108(3):878-85. doi: 10.1182/blood-2005-11-4545. Epub 2006 Feb 28.
Abstract
Current models predict that mouse plasmacytoid dendritic cells (PDCs) derive from lymphoid progenitors. However, we show PDCs arise exclusively from common myeloid progenitors (CMPs) characterized by low-level expression of several lymphoid-associated genes, including a RAG2/GFP reporter transgene. This conclusion is supported by both adoptive transfer experiments and an estrogen treatment strategy that led to marked depletion of very early lymphoid progenitors without affecting RAG2/GFP(+) CMPs or the developmental kinetics, RAG-mediated recombinase activity, and cytokine production of PDCs. These data suggest that PDCs arise exclusively from early myeloid progenitors and that promiscuous low-level expression of lymphoid-associated genes is a general feature of PDC progenitors among CMPs.
摘要
目前的模型预测小鼠浆细胞样树突状细胞（pDC）来源于淋巴祖细胞。然而，我们发现pDC仅来源于普通髓系祖细胞（CMP），其特征是包括RAG2/GFP报告转基因在内的几种淋巴相关基因低水平表达。这一结论得到了过继转移实验和雌激素处理策略的支持，雌激素处理策略导致极早期淋巴祖细胞显著耗竭，而不影响RAG2/GFP(+) CMP或pDC的发育动力学、RAG介导的重组酶活性及细胞因子产生。这些数据表明，pDC仅来源于早期髓系祖细胞，且淋巴相关基因的混杂低水平表达是CMP中pDC祖细胞的普遍特征。
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