使用心脏探头测量经皮硝酸甘油对冠状动脉疾病患者左心室功能的影响。

Measurements of the effects of percutaneous nitroglycerin on left ventricular performance in patients with coronary artery disease with a cardiac probe.

作者信息

He Z X, Kou R W, Liu X J

机构信息

Department of Nuclear Medicine, Fu Wai Hospital, Beijing, Peoples Republic of China.

出版信息

Eur J Nucl Med. 1988;14(7-8):374-7. doi: 10.1007/BF00254387.

DOI:10.1007/BF00254387

PMID:3141188

Abstract

Left ventricular function was measured after percutaneous nitroglycerin in ten patients with coronary artery disease under double blind random control. The elevation of LVEF after percutaneous nitroglycerin paste (containing 10 mg nitroglycerin) was 8.3% +/- 1.3% (P less than 0.001) at 30 min, 8.5% +/- 1.8% (P less than 0.001) at 60 min, 10.1% +/- 1.8% (P less than 0.001) at 90 min and 8.7% +/- 2.2% (P less than 0.01) at 120 min respectively, but the change of LVEF after nitroglycerin ointment (containing 5 mg nitroglycerin) was not significant. The elevation of ER and RCO after nitroglycerin paste were 0.448 +/- 0.088 (EDV/s) (P less than 0.001), 6.73 +/- 1.47 (EDV/s) (P less than 0.01) at 30 min, 0.376 +/- 0.078 (P less than 0.001), 6.64 +/- 1.36 (P less than 0.001) at 60 min, 0.456 +/- 0.089 (P less than 0.001), 8.02 +/- 2.11 (P less than 0.001) at 90 min and 0.358 +/- 0.076 (P less than 0.01), 6.18 +/- 2.05 (P less than 0.01) respectively. It was demonstrated that percutaneous nitroglycerin paste (10 mg nitroglycerin) can improve the left ventricular function of patients with coronary artery disease.

摘要

在双盲随机对照条件下，对10例冠心病患者经皮给予硝酸甘油后测量左心室功能。经皮给予硝酸甘油贴剂（含10mg硝酸甘油）后，左室射血分数（LVEF）在30分钟时升高8.3%±1.3%（P<0.001），60分钟时升高8.5%±1.8%（P<0.001），90分钟时升高10.1%±1.8%（P<0.001），120分钟时升高8.7%±2.2%（P<0.01），但硝酸甘油软膏（含5mg硝酸甘油）后LVEF的变化不显著。硝酸甘油贴剂后舒张末期弹性（ER）和舒张末期室壁运动速度比值（RCO）在30分钟时分别为0.448±0.088（EDV/s）（P<0.001）、6.73±1.47（EDV/s）（P<0.01），60分钟时为0.376±0.078（P<0.001）、6.64±1.36（P<0.001），90分钟时为0.456±0.089（P<0.001）、8.02±2.11（P<0.001），120分钟时分别为0.358±0.076（P<0.01）、6.18±2.05（P<0.01）。结果表明，经皮硝酸甘油贴剂（10mg硝酸甘油）可改善冠心病患者的左心室功能。