用心脏探头监测α-人心房利钠多肽（α-hANP）对原发性高血压患者左心室功能的影响。
Monitoring effects of alpha-human atrial natriuretic polypeptide (alpha-hANP) on left ventricular function in patients with essential hypertension with a cardiac probe.
作者信息
Liu X J, Liu Y Z, He Z X, Zhou B G, Liu L S, Wagner H N
机构信息
Department of Nuclear Medicine, Chinese Academy of Medical Sciences, Beijing.
出版信息
Eur J Nucl Med. 1987;13(7):335-7. doi: 10.1007/BF00252990.
The effects of alpha-hANP on left ventricular function were studied with a cardiac probe in ten patients with essential hypertension. Our data showed that intravenous administration of alpha-hANP significantly elevated left ventricular function. At 5 min, the elevation of EF, RCO, ER, RSV, PFR were 13.23% (P less than 0.02), 12.7 (P less than 0.02), 0.618 (P less than 0.02), 0.133 (P less than 0.05), 0.283 (P less than 0.01), respectively. At 10 min, the increase of EF, ER, were 11.07% (P less than 0.02) and 0.233 (P less than 0.01), respectively. Atriopeptin significantly reduced systolic and diastolic blood pressure from 2 min to 20 min (P less than 0.001-0.05).
用心脏探头对10例原发性高血压患者研究了α-人心房钠尿肽（α-hANP）对左心室功能的影响。我们的数据表明，静脉注射α-hANP可显著提高左心室功能。5分钟时，射血分数（EF）、右心输出量（RCO）、舒张末期弹性（ER）、快速充盈速率（RSV）、射血前期（PFR）的升高分别为13.23%（P<0.02）、12.7（P<0.02）、0.618（P<0.02）、0.133（P<0.05）、0.283（P<0.01）。10分钟时，EF、ER的增加分别为11.07%（P<0.02）和0.233（P<0.01）。心钠素在2分钟至20分钟显著降低收缩压和舒张压（P<0.001至0.05）。
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