鱿鱼巨大突触中的突触前电位与递质释放的易化作用。
Presynaptic potentials and facilitation of transmitter release in the squid giant synapse.
作者信息
Charlton M P, Bittner G D
出版信息
J Gen Physiol. 1978 Oct;72(4):487-511. doi: 10.1085/jgp.72.4.487.
Presynaptic potentials were studied during facilitation of transmitter release in the squid giant synapse. Changes in action potentials were found to cause some, but not all, of the facilitation during twin-pulse stimulation. During trains of action potentials, there were no progressive changes in presynaptic action potentials which could account for the growth of facilitation. Facilitation could still be detected in terminals which had undergone conditioning depolarization or hyperpolarization. Facilitation could be produced by small action potentials in low [Ca++]o and by small depolarizations in the presence of tetrodotoxin. Although the production of facilitation varied somewhat with presynaptic depolarization, nevertheless, approximately equal amounts of facilitation could be produced by depolarizations which caused the release of very different amounts of transmitter.
在枪乌贼巨大突触中递质释放的易化过程中，对突触前电位进行了研究。发现在双脉冲刺激期间，动作电位的变化会引起部分而非全部的易化。在一串动作电位期间，突触前动作电位没有渐进性变化，而这种变化本可解释易化的增强。在经历过条件性去极化或超极化的终末中，仍可检测到易化。在低细胞外钙离子浓度（[Ca++]o）时，小的动作电位以及在存在河豚毒素时的小去极化都可产生易化。尽管易化的产生随突触前去极化而有所不同，然而，引起非常不同量递质释放的去极化可产生大致等量的易化。
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