Llinás R, Sugimori M, Simon S M
Proc Natl Acad Sci U S A. 1982 Apr;79(7):2415-9. doi: 10.1073/pnas.79.7.2415.
Synaptic transmission produced by artificially generated presynaptic depolarizations, having the same waveform as normal presynaptic action potentials, was studied in the squid giant synapse. These stimulated spikes produced synaptic transmission virtually indistinguishable from that obtained with the original presynaptic spike activation. The technique allows a direct determination of the onset and amplitude of the Ca current, ICa, triggered by the presynaptic action potential and the relationship between ICa and postsynaptic response. The results closely resemble theoretical predictions by a previously published model for synaptic transmission in this synapse and demonstrate that ICa occurs at the falling phase of the presynaptic spike.
在枪乌贼巨大突触中，研究了由人工产生的具有与正常突触前动作电位相同波形的突触前去极化所产生的突触传递。这些刺激产生的尖峰所引发的突触传递，实际上与原始突触前尖峰激活所获得的突触传递无法区分。该技术能够直接测定由突触前动作电位触发的钙电流（ICa）的起始和幅度，以及ICa与突触后反应之间的关系。结果与之前发表的该突触突触传递模型的理论预测非常相似，并表明ICa出现在突触前尖峰的下降阶段。
