Department of Emergency Medicine, the Third Hospital of Hebei Medical University, No. 139 Ziqiang Road, Shijiazhuang, 050051, Hebei, China.
Department of Nutrition and Diet, the Third Hospital of Hebei Medical University, No. 139 Ziqiang Road, Shijiazhuang, 050051, Hebei, China.
J Orthop Surg Res. 2019 Aug 14;14(1):257. doi: 10.1186/s13018-019-1310-y.
To evaluate the effect of oral Lactobacillus casei Shirota (LcS) administration on recovery of hand functions in senior patients diagnosed with an acute distal radius fracture.
This clinical trial is double-blind and placebo-controlled, in which 293 senior patients with distal radius fracture were initially enrolled. After exclusion, 264 eligible patients were randomly assigned to receive oral placebo or LcS daily for a period of 3 months after the fracture. Treatment outcomes were Michigan Hand Questionnaire (MHQ) score, radial deviation and inclination, and ulnar deviation and variance, all of which were monitored and measured every month.
Throughout the length of this study, MHQ score, radial deviation and inclination, and ulnar deviation and variance of patients on oral LcS displayed a significantly faster improvement in comparison to those receiving placebo, over the 3-month intervention period.
Oral administration of LcS dramatically accelerated hand function recovery in senior patients with distal radius fracture.
评估口服干酪乳杆菌 Shirota（LcS）对诊断为急性桡骨远端骨折的老年患者手部功能恢复的影响。
这是一项双盲、安慰剂对照的临床试验，最初纳入了 293 名桡骨远端骨折的老年患者。排除后，264 名符合条件的患者被随机分配接受口服安慰剂或 LcS，每天一次，持续 3 个月。治疗结果为密歇根手问卷（MHQ）评分、桡偏和倾斜度以及尺偏和方差，所有这些都在每个月进行监测和测量。
在整个研究过程中，口服 LcS 的患者的 MHQ 评分、桡偏和倾斜度以及尺偏和方差在 3 个月的干预期间，与接受安慰剂的患者相比，改善速度明显更快。
口服 LcS 可显著加速老年桡骨远端骨折患者手部功能的恢复。
