肠道-骨骼信号传导中的益生菌
Probiotics in Gut-Bone Signaling.
作者信息
Schepper Jonathan D, Irwin Regina, Kang Jun, Dagenais Kevin, Lemon Tristan, Shinouskis Ally, Parameswaran Narayanan, McCabe Laura R
机构信息
Department of Physiology, Michigan State University, East Lansing, MI, USA.
Comparative Medicine and Integrative Biology Program, East Lansing, MI, USA.
出版信息
Adv Exp Med Biol. 2017;1033:225-247. doi: 10.1007/978-3-319-66653-2_11.
Abstract
The intestinal environment is linked to an array of conditions and diseases, including osteoporosis. Human and animal studies indicate that probiotics can benefit intestinal health and may provide a useful therapeutic to prevent and/or treat bone loss. Probiotics are defined as live microorganisms that when administered in adequate amounts will confer a health benefit on the host. In this review, we will focus on (1) probiotics (definition, history, nomenclature, types), (2) the effects of probiotics on bone health, and (3) mechanisms of probiotic prevention of bone pathologies.
摘要
肠道环境与一系列病症和疾病相关，包括骨质疏松症。人体和动物研究表明，益生菌有益于肠道健康，可能为预防和/或治疗骨质流失提供有效的治疗方法。益生菌被定义为适量施用时会给宿主带来健康益处的活微生物。在本综述中，我们将重点关注：（1）益生菌（定义、历史、命名、类型），（2）益生菌对骨骼健康的影响，以及（3）益生菌预防骨骼疾病的机制。
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