Moulder J E, Fish B L
Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee 53226.
Int J Radiat Oncol Biol Phys. 1988 Nov;15(5):1193-6. doi: 10.1016/0360-3016(88)90203-9.
Oxygen carrying perfluorochemical emulsions have been shown to enhance the response of animal tumors to large single doses of radiation. Clinically, however, perfluorochemical emulsions are being used with only some fractions in multiple fraction radiation courses. To test the efficacy of a perfluorochemical emulsion under conditions that are closer to those used in current clinical trials, BA1112 rat sarcomas were treated with three fractions per week of 6 Gy per fraction. Once a week, animals were infused i.v. with a perfluorochemical emulsion at 15 ml/kg, and allowed to breathe carbogen (95% O2:5% CO2) for 30 minutes prior to and during irradiation. The 50% tumor control dose was 93.1 (87.9-103.1) Gy in the control arm compared to 74.3 (64.9-83.9) Gy for the animals given the perfluorochemical infusion plus carbogen breathing. The dose modification factor for intermittent perfluorochemical infusion and carbogen breathing was 1.26 (1.15-1.40). In a similar fractionated schedule, the hypoxic cell radiosensitizer, misonidazole, given once per week at 600 mg/kg, gave a dose modification factor of 1.22 (1.14-1.32).
携氧全氟化合物乳剂已被证明可增强动物肿瘤对大剂量单次辐射的反应。然而在临床上，全氟化合物乳剂仅在多分割放疗疗程的部分分割中使用。为了在更接近当前临床试验所用条件下测试全氟化合物乳剂的疗效，对BA1112大鼠肉瘤每周进行3次分割照射，每次6 Gy。每周一次，给动物静脉输注15 ml/kg的全氟化合物乳剂，并在照射前和照射期间让动物呼吸含95%氧气和5%二氧化碳的混合气30分钟。对照组的50%肿瘤控制剂量为93.1（87.9 - 103.1）Gy，而接受全氟化合物输注加呼吸含95%氧气和5%二氧化碳混合气的动物为74.3（64.9 - 83.9）Gy。间歇性全氟化合物输注和呼吸含95%氧气和5%二氧化碳混合气的剂量修正因子为1.26（1.15 - 1.40）。在类似的分割方案中，每周一次给予600 mg/kg的乏氧细胞放射增敏剂米索硝唑，剂量修正因子为1.22（1.14 - 1.32）。
