Department of Biomedical Systems Informatics and Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
Department of Veterinary Pathology, Small Animal Tumor Diagnostic Center, College of Veterinary Medicine, Konkuk University, Seoul, 05029, Republic of Korea.
Sci Data. 2019 Aug 14;6(1):147. doi: 10.1038/s41597-019-0149-8.
Studies of naturally occurring cancers in dogs, which share many genetic and environmental factors with humans, provide valuable information as a comparative model for studying the mechanisms of human cancer pathogenesis. While individual and small-scale studies of canine cancers are underway, more generalized multi-omics studies have not been attempted due to the lack of large-scale and well-controlled genomic data. Here, we produced reliable whole-exome and whole-transcriptome sequencing data of 197 canine mammary cancers and their matched controls, annotated with rich clinical and biological features. Our dataset provides useful reference points for comparative analysis with human cancers and for developing novel diagnostic and therapeutic technologies for cancers in pet dogs.
对与人类具有许多遗传和环境因素的犬类自然发生的癌症的研究，为研究人类癌症发病机制提供了有价值的比较模型信息。虽然正在进行针对犬类癌症的个体和小规模研究，但由于缺乏大规模和良好控制的基因组数据，尚未尝试进行更广泛的多组学研究。在这里，我们生成了 197 例犬乳腺肿瘤及其匹配对照的可靠全外显子组和全转录组测序数据，并附有丰富的临床和生物学特征注释。我们的数据集为与人类癌症进行比较分析以及为宠物犬癌症开发新的诊断和治疗技术提供了有用的参考点。
