一种新型免疫调节剂，FR - 900490。

A new immunomodulator, FR-900490.

作者信息

Shibata T, Nakayama O, Okuhara M, Tsurumi Y, Terano H, Kohsaka M

机构信息

Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.

出版信息

J Antibiot (Tokyo). 1988 Sep;41(9):1163-9. doi: 10.7164/antibiotics.41.1163.

DOI:10.7164/antibiotics.41.1163

PMID:3141334

Abstract

FR-900490 is a new type of immunoactive substance produced by a fungus Discosia sp. F-11809. The colony forming units in culture (cfu-c) in bone marrow cells, which were suppressed by immunosuppressive factor obtained from the serum of sarcoma 180 tumor bearing mouse, was restored to normal level by the addition of FR-900490 in vitro. Furthermore, in mitomycin C (MMC)-treated mice the subsequent administration of FR-900490 caused a significant increase of cfu-c in bone marrow cells depressed by MMC.

摘要

FR - 900490是由真菌盘菌属（Discosia sp.）F - 11809产生的一种新型免疫活性物质。肉瘤180荷瘤小鼠血清中获得的免疫抑制因子可抑制骨髓细胞中的培养集落形成单位（cfu - c），在体外添加FR - 900490后，其可恢复至正常水平。此外，在丝裂霉素C（MMC）处理的小鼠中，随后给予FR - 900490可使被MMC抑制的骨髓细胞中的cfu - c显著增加。