一种新型免疫调节剂，FR-900483。

A new immunomodulator, FR-900483.

作者信息

Shibata T, Nakayama O, Tsurumi Y, Okuhara M, Terano H, Kohsaka M

机构信息

Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.

出版信息

J Antibiot (Tokyo). 1988 Mar;41(3):296-301. doi: 10.7164/antibiotics.41.296.

DOI:10.7164/antibiotics.41.296

PMID:3366688

Abstract

FR-900483 is a new immunoactive substance produced by a fungus, Nectria lucida F-4490. Concanavalin A-stimulated lymphocyte proliferation, which had been suppressed by addition of immunosuppressive factor, was restored to a normal level by the addition of FR-900483. Furthermore, FR-900483 restored the capacity of immunosuppressed mice to produce antibody against sheep red blood cells.

摘要

FR - 900483是一种由真菌亮红丛赤壳菌F - 4490产生的新型免疫活性物质。添加免疫抑制因子后被抑制的伴刀豆球蛋白A刺激的淋巴细胞增殖，通过添加FR - 900483恢复到正常水平。此外，FR - 900483恢复了免疫抑制小鼠产生抗绵羊红细胞抗体的能力。