Department of Hematology, Blood Neoplasms and Bone Marrow Transplantation, Wroclaw Medical University, Poland.
Adv Clin Exp Med. 2019 Aug;28(8):1119-1124. doi: 10.17219/acem/94068.
Although gastrointestinal (GI) tract is the most common extranodal site involved in non-Hodgkin lymphoma (NHL), primary gastrointestinal NHL (gNHL) is a rare problem which concerns about 10-15% of NHL patients and 30-40% of extranodal NHL patients. Lymphoid neoplasms may consist of mature B, T and (less commonly) extranodal NK/T cells. The most common diagnoses are diffuse large B-cell lymphoma and marginal zone lymphoma (MALT), but many other lymphomas may be found in the GI tract. There are a few well-known risk factors of gNHL and some of them affect treatment. The most frequent sites of occurrence are the stomach followed by small intestine and ileocecal region. In the last 2 decades, there has been a rapid development in the diagnosis, staging and management of GI lymphoma, but still some of such lymphomas, especially T-cell ones, are a therapeutic challenge. In this review, we present clinical and pathological features of GI lymphomas. We also describe the current status in diagnosis and treatment.
虽然胃肠道（GI）是最常见的非霍奇金淋巴瘤（NHL）结外累及部位，但原发性胃肠道 NHL（gNHL）是一个罕见的问题，约占 NHL 患者的 10-15%和结外 NHL 患者的 30-40%。淋巴肿瘤可能由成熟 B、T 和（较少见的）结外 NK/T 细胞组成。最常见的诊断是弥漫性大 B 细胞淋巴瘤和边缘区淋巴瘤（MALT），但 GI tract 中也可能存在许多其他淋巴瘤。有一些众所周知的 gNHL 危险因素，其中一些会影响治疗。最常发生的部位是胃，其次是小肠和回盲部。在过去的 20 年中，GI 淋巴瘤的诊断、分期和治疗有了快速发展，但仍有一些此类淋巴瘤，尤其是 T 细胞淋巴瘤，是治疗上的挑战。在这篇综述中，我们介绍了 GI 淋巴瘤的临床和病理特征。我们还描述了目前的诊断和治疗现状。
