C反应蛋白/白蛋白比值作为乙型肝炎病毒相关性失代偿期肝硬化患者死亡率的预测指标
The C-Reactive Protein/Albumin Ratio as a Predictor of Mortality in Patients with HBV-Related Decompensated Cirrhosis.
作者信息
Wang Chun-Jiang, Wu Jian-Ping, Zhou Wu-Qiong, Mao Wei-Lin, Huang Hang-Bin
出版信息
Clin Lab. 2019 Aug 1;65(8). doi: 10.7754/Clin.Lab.2019.190215.
BACKGROUND
The C-reactive protein to albumin ratio (CAR) is a novel inflammation index that has recently been used as a marker for poor prognosis or mortality in various patient groups. This study aimed to evaluate the association between the CAR and 30-day mortality in patients with hepatitis B virus-related decompensated cirrhosis (HBV-DeCi).
METHODS
This was a retrospective cohort study of 113 patients who had been diagnosed with HBV-DeCi. Univariate and multivariate regression models were used to determine risk factors for mortality.
RESULTS
The CAR was observed to be significantly higher in the non-surviving patients compared to the surviving patients. Moreover, the CAR was positively correlated with the model for end-stage liver disease (MELD) score and Child-Pugh score. In multivariate analysis, the CAR and the MELD score were independent prognostic factors for HBV-DeCi patients.
CONCLUSIONS
A high CAR value at admission can serve as an independent predictor of 1-month mortality in patients with HBV-DeCi.
背景
C反应蛋白与白蛋白比值（CAR）是一种新型炎症指标，最近已被用作各类患者群体预后不良或死亡的标志物。本研究旨在评估CAR与乙型肝炎病毒相关失代偿性肝硬化（HBV-DeCi）患者30天死亡率之间的关联。
方法
这是一项对113例被诊断为HBV-DeCi患者的回顾性队列研究。采用单因素和多因素回归模型确定死亡的危险因素。
结果
观察到非存活患者的CAR显著高于存活患者。此外，CAR与终末期肝病模型（MELD）评分和Child-Pugh评分呈正相关。在多因素分析中，CAR和MELD评分是HBV-DeCi患者的独立预后因素。
结论
入院时高CAR值可作为HBV-DeCi患者1个月死亡率的独立预测指标。
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