HBV 相关肝脏疾病的血清生物标志物及其衍生模型的综述。
Review of Serum Biomarkers and Models Derived from Them in HBV-Related Liver Diseases.
机构信息
Department of Clinical Laboratory, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province 310003, China.
出版信息
Dis Markers. 2020 Jul 21;2020:2471252. doi: 10.1155/2020/2471252. eCollection 2020.
Abstract
A series of predictive scoring systems is available for stratifying the severity of conditions and assessing the prognosis in patients with HBV-related liver diseases. We show nine of the most popular serum biomarkers and their models (i.e., serum cystatin C, homocysteine, C-reactive protein, C-reactive protein to albumin ratio, aspartate aminotransferase to platelet ratio index, fibrosis index based on four factors, gamma-glutamyl transpeptidase to platelet ratio, albumin-bilirubin score, and gamma-glutamyl transpeptidase to albumin ratio) that have gained great interest from clinicians. Compared with traditional scoring systems, these serum biomarkers and their models are easily acquired, simple, and relatively inexpensive. In the present review, we summarize the latest studies focused on these serum biomarkers and their models as diagnostic and prognostic indexes in HBV-related liver diseases.
摘要
有一系列预测评分系统可用于对 HBV 相关肝病患者的病情严重程度进行分层，并评估其预后。我们展示了其中最受欢迎的九种血清生物标志物及其模型（即血清胱抑素 C、同型半胱氨酸、C 反应蛋白、C 反应蛋白与白蛋白比值、天冬氨酸氨基转移酶与血小板比值指数、基于四个因素的纤维化指数、γ-谷氨酰转肽酶与血小板比值、白蛋白-胆红素评分和γ-谷氨酰转肽酶与白蛋白比值），这些标志物及其模型受到了临床医生的广泛关注。与传统的评分系统相比，这些血清生物标志物及其模型易于获取、简单且相对便宜。在本综述中，我们总结了这些血清生物标志物及其模型作为 HBV 相关肝病的诊断和预后指标的最新研究。
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