Department of Oncology, Monash Health, and School of Clinical Sciences, Monash University, Melbourne, Australia; Prince of Wales Clinical School UNSW, and Department of Medical Oncology, Prince of Wales Hospital, Sydney, Australia.
National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, Australia.
Gynecol Oncol. 2019 Oct;155(1):126-134. doi: 10.1016/j.ygyno.2019.08.009. Epub 2019 Aug 13.
Our aim was to investigate the prevalence and potential risk factors for persistent and troublesome physical and psychological symptoms following treatment for ovarian cancer (OC).
OvQuest is an international, internet-based, cross-sectional questionnaire which explored symptom burden and quality of life (QOL) after treatment for OC. Eligible women were aged 18 and over, diagnosed with OC at least 6 months previously and had received chemotherapy. Self-report data were collected including demographics, diagnosis and treatment, and standardised instruments for treatment-related toxicities, QOL, physical activity (PA) and supportive care needs.
The survey included 1360 patients, of whom 421 (31%) had been treated for recurrent OC. 78% reported symptoms of peripheral neuropathy, 60% significant fatigue, 48% mood disturbance and 59% moderate-severe insomnia. Rates of fatigue, mood disorders, neuropathy and insomnia did not differ between women with or without recurrence. The majority of respondents were overweight or obese (high BMI, 59%) and 35% reported low PA. Low PA and high BMI were associated with poorer QOL scores and higher symptom burden across a range of domains.
Women living after a diagnosis of OC report a substantial and ongoing symptom burden which impacts significantly on their quality of life across multiple domains. The reported associations between obesity, physical inactivity and poor QOL warrant prospective evaluation of lifestyle interventions to improve QOL.
本研究旨在调查卵巢癌（OC）治疗后持续存在的躯体和心理症状及其潜在危险因素。
OvQuest 是一项国际性的、基于互联网的、横断面问卷调查，旨在调查 OC 治疗后患者的症状负担和生活质量（QOL）。符合条件的患者年龄≥18 岁，确诊 OC 至少 6 个月，且接受过化疗。收集的自我报告数据包括人口统计学、诊断和治疗信息，以及与治疗相关的毒性、QOL、体力活动（PA）和支持性护理需求的标准化工具。
该研究共纳入 1360 例患者，其中 421 例（31%）为复发性 OC 患者。78%的患者报告有周围神经病变症状，60%的患者有明显疲劳，48%的患者有情绪障碍，59%的患者有中度至重度失眠。有无复发的患者之间疲劳、情绪障碍、神经病变和失眠的发生率无差异。大多数患者超重或肥胖（高 BMI，59%），35%的患者报告体力活动水平低。低 PA 和高 BMI 与多个领域的 QOL 评分和更高的症状负担相关。
诊断为 OC 后生存的女性报告了大量持续存在的症状负担，这对她们的生活质量产生了重大影响，涉及多个领域。肥胖、身体活动不足和 QOL 差之间的相关性表明，需要前瞻性评估生活方式干预以改善 QOL。
