Smits Anke, Lopes Alberto, Das Nagindra, Bekkers Ruud, Galaal Khadra
*Department of Obstetrics and Gynaecology, Royal Cornwall Hospital, Truro, United Kingdom; and †Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands.
Int J Gynecol Cancer. 2015 May;25(4):616-21. doi: 10.1097/IGC.0000000000000388.
In this study, we evaluated the effect of body mass index (BMI) on the quality of life of ovarian cancer survivors.
Women diagnosed with ovarian cancer at the Royal Cornwall Hospital Trust between January 2008 and May 2013 were identified. Ovarian cancer survivors were invited to participate by completing the European Organization for Research and Treatment of Cancer QLQ-C30 (quality of life) questionnaire. Univariate and multiple regression analyses were used to determine associations between BMI and quality-of-life outcomes.
A total of 176 ovarian cancer survivors were invited to participate, of which 133 were eligible for this study. In total, 81 ovarian cancer survivors (60.4%) completed the questionnaire, of which 26 responders (32.1%) were overweight (BMI, 25-29.9 kg/m²) and 27 (33.3%) were obese (BMI, ≥30 kg/m²). Increasing BMI was significantly associated with poorer quality-of-life outcomes in terms of physical functioning and emotional functioning, and this effect persisted for physical functioning after multiple regression analysis.
Increasing BMI is associated with poorer quality-of-life outcomes in terms of physical and emotional functioning in ovarian cancer survivors. Further research is needed to evaluate the association between BMI and quality of life from diagnosis to survivorship to develop novel interventions.
在本研究中，我们评估了体重指数（BMI）对卵巢癌幸存者生活质量的影响。
确定了2008年1月至2013年5月期间在皇家康沃尔医院信托基金被诊断为卵巢癌的女性。邀请卵巢癌幸存者通过填写欧洲癌症研究与治疗组织QLQ-C30（生活质量）问卷来参与研究。采用单因素和多因素回归分析来确定BMI与生活质量结果之间的关联。
共邀请了176名卵巢癌幸存者参与，其中133名符合本研究条件。总共有81名卵巢癌幸存者（60.4%）完成了问卷，其中26名应答者（32.1%）超重（BMI，25 - 29.9 kg/m²），27名（33.3%）肥胖（BMI，≥30 kg/m²）。就身体功能和情绪功能而言，BMI升高与较差的生活质量结果显著相关，并且在多因素回归分析后，这种影响在身体功能方面仍然存在。
就身体和情绪功能而言，BMI升高与卵巢癌幸存者较差的生活质量结果相关。需要进一步研究来评估从诊断到存活期BMI与生活质量之间的关联，以开发新的干预措施。
