Institut Curie, Paris Sciences et Lettres (PSL) Research University, Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 3348, F-91405 Orsay, France; Université Paris Sud, Université Paris-Saclay, CNRS UMR 3348, F-91405 Orsay, France.
Center for Geroscience, Brain Health, and Metabolism (GERO), Santiago, Chile; Department of Biology, Faculty of Sciences, University of Chile, Santiago, Chile.
Trends Cell Biol. 2019 Oct;29(10):804-819. doi: 10.1016/j.tcb.2019.07.004. Epub 2019 Aug 12.
Microtubule-associated proteins (MAPs) were initially discovered as proteins that bind to and stabilize microtubules. Today, an ever-growing number of MAPs reveals a more complex picture of these proteins as organizers of the microtubule cytoskeleton that have a large variety of functions. MAPs enable microtubules to participate in a plethora of cellular processes such as the assembly of mitotic and meiotic spindles, neuronal development, and the formation of the ciliary axoneme. Although some subgroups of MAPs have been exhaustively characterized, a strikingly large number of MAPs remain barely characterized other than their interactions with microtubules. We provide a comprehensive view on the currently known MAPs in mammals. We discuss their molecular mechanisms and functions, as well as their physiological role and links to pathologies.
微管相关蛋白（MAPs）最初被发现为与微管结合并稳定微管的蛋白。如今，越来越多的 MAPs 揭示了这些蛋白质作为微管细胞骨架组织者的更复杂的图景，它们具有多种功能。MAPs 使微管能够参与多种细胞过程，例如有丝分裂和减数分裂纺锤体的组装、神经元发育和纤毛轴丝的形成。尽管一些 MAPs 亚组已经被详尽地描述，但仍然有大量的 MAPs 除了与微管的相互作用外，几乎没有被描述。我们提供了哺乳动物中目前已知的 MAPs 的全面视图。我们讨论了它们的分子机制和功能，以及它们的生理作用和与病理学的联系。
