Department of Neurobiology, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
Learn Mem. 2019 Aug 15;26(9):343-350. doi: 10.1101/lm.048876.118. Print 2019 Sep.
Gene transcription is a crucial step in the sequence of molecular, synaptic, cellular, and systems mechanisms underlying learning and memory. Here, we review the experimental evidence demonstrating that alterations in the levels and functionality of the methylated DNA-binding transcriptional regulator MeCP2 are implicated in the learning and memory deficits present in mouse models of Rett syndrome and duplication syndrome. The significant impact that MeCP2 has on gene transcription through a variety of mechanisms, combined with well-defined models of learning and memory, make MeCP2 an excellent candidate to exemplify the role of gene transcription in learning and memory. Together, these studies have strengthened the concept that precise control of activity-dependent gene transcription is a fundamental mechanism that ensures long-term adaptive behaviors necessary for the survival of individuals interacting with their congeners in an ever-changing environment.
基因转录是学习和记忆所涉及的分子、突触、细胞和系统机制序列中的关键步骤。在这里，我们回顾了实验证据，证明甲基化 DNA 结合转录调节因子 MeCP2 的水平和功能的改变与 Rett 综合征和重复综合征小鼠模型中存在的学习和记忆缺陷有关。MeCP2 通过多种机制对基因转录产生重大影响，并且具有明确的学习和记忆模型，这使其成为例证基因转录在学习和记忆中作用的优秀候选者。这些研究共同加强了这样一种概念，即活性依赖性基因转录的精确控制是一种基本机制，它确保了个体与不断变化的环境中的同类进行互动时所需的长期适应性行为。
