Dai Xiaotong, Yang Ying, Cheng Guan-Liang, Jia Jia, Fan Fang-Fang, Li Jian-Ping, Huo Yong, Liu Zhike, Chen Dafang, Zhang Yan
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, People's Republic of China.
Department of Cardiology, Peking University First Hospital, Beijing, People's Republic of China.
Diabetes Metab Syndr Obes. 2019 Jun 24;12:901-911. doi: 10.2147/DMSO.S195405. eCollection 2019.
Increased arterial stiffness measured by brachial-ankle pulse wave velocity is associated with cardiovascular disease. However, the rates at which brachial-ankle pulse wave velocity and blood glucose accelerate within individuals who differ in blood pressure levels are largely unknown. This study was based on the baseline data of a Chinese community-based atherosclerosis cohort which included 7402 individuals. Using generalized linear regression models, the relationship between blood glucose levels and brachial-ankle pulse wave velocity, and the relationship between blood pressure levels and brachial-ankle pulse wave velocity were examined. A marked interaction between hypertensive state and diabetic state was seen for brachial-ankle pulse wave velocity ( for interaction <0.001). The adjusted coefficient for subjects stratified by hypertensive groups and diabetic states showed that the highest brachial-ankle pulse wave velocity risk subjects were those who had both diabetes and hypertension (B=403.24; 95% CI: 372.43-434.05; <0.001). The participants with increased arterial stiffness demonstrate a high prevalence of higher blood pressure. When high blood glucose levels co-occur with high blood pressure levels, there is a remarkable increase in arterial stiffness.
通过臂踝脉搏波速度测量的动脉僵硬度增加与心血管疾病相关。然而，在血压水平不同的个体中，臂踝脉搏波速度和血糖加速的速率在很大程度上尚不清楚。本研究基于一个中国社区动脉粥样硬化队列的基线数据，该队列包括7402名个体。使用广义线性回归模型，研究了血糖水平与臂踝脉搏波速度之间的关系，以及血压水平与臂踝脉搏波速度之间的关系。臂踝脉搏波速度在高血压状态和糖尿病状态之间存在显著的交互作用（交互作用P<0.001）。按高血压组和糖尿病状态分层的受试者的校正系数显示，臂踝脉搏波速度风险最高的受试者是那些同时患有糖尿病和高血压的人（B=403.24；95%CI：372.43 - 434.05；P<0.001）。动脉僵硬度增加的参与者表现出高血压的高患病率。当高血糖水平与高血压水平同时出现时，动脉僵硬度会显著增加。
