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临床常规环境下治疗后随访中晚期功能结局的监测与评估

Monitoring and Evaluation of Late Functional Outcome in Post-treatment Follow-Up in Clinical Routine Setting.

作者信息

Zebralla Veit, Meuret Sylvia, Wiegand Susanne

机构信息

Clinic of Otolaryngology, Head and Neck Surgery, University Hospital Leipzig, Leipzig, Germany.

出版信息

Front Oncol. 2019 Jul 30;9:700. doi: 10.3389/fonc.2019.00700. eCollection 2019.

DOI:10.3389/fonc.2019.00700
PMID:31417873
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6682590/
Abstract

Patients treated for head and neck cancer (HNC) often suffer from severe and visible loss of function as the cancer itself and the side effects of aggressive treatments have the potential to severely affect quality of life. Therefore, the aim of follow-up is not only the early detection of potentially curable recurrences and second primary tumors but also the diagnosis and rehabilitation of functional impairments. Clear guidelines determining the frequency of follow-up visits are missing, and the impact of follow-up visits on patient's prognosis is unclear. An intensive post-treatment follow-up is needed to detect functional impairments and to initiate their treatment. The aim is an optimal rehabilitation of the patients. This article focusses on goals of aftercare treatment and describes the spectrum of long-term sequelae, and the impact of Patient Reported Outcome (PRO) instruments of which three will be introduced.

摘要

头颈部癌症(HNC)患者在接受治疗后,往往会出现严重且明显的功能丧失,因为癌症本身以及积极治疗产生的副作用可能会严重影响生活质量。因此,随访的目的不仅是早期发现潜在可治愈的复发和第二原发性肿瘤,还包括功能障碍的诊断与康复。目前尚缺乏明确规定随访频率的指南,且随访对患者预后的影响也不明确。需要进行强化的治疗后随访,以检测功能障碍并启动相应治疗。目标是实现患者的最佳康复。本文重点关注后续治疗的目标,描述长期后遗症的范围,以及将介绍的三种患者报告结局(PRO)工具的影响。

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本文引用的文献

1
Early detection of esophageal second primary tumors using Lugol chromoendoscopy in patients with head and neck cancer: A systematic review and meta-analysis.头颈部癌患者应用卢戈氏染色内镜早期检测食管第二原发肿瘤:系统评价和荟萃分析。
Head Neck. 2019 Apr;41(4):1122-1130. doi: 10.1002/hed.25548. Epub 2018 Dec 28.
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Swallowing-related quality of life after free flap surgery due to cancer of the head and neck.头颈部癌症游离皮瓣手术后吞咽相关的生活质量
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Changes in incidence and prevalence of human papillomavirus in tonsillar and base of tongue cancer during 2000-2016 in the Stockholm region and Sweden.2000-2016 年斯德哥尔摩地区和瑞典扁桃体和舌底癌人乳头瘤病毒发病率和流行率的变化。
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Otolaryngol Head Neck Surg. 2019 Jun;160(6):1023-1033. doi: 10.1177/0194599818818443. Epub 2018 Dec 11.
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Psychosocial Effects of Head and Neck Cancer.头颈癌的社会心理影响
Oral Maxillofac Surg Clin North Am. 2018 Nov;30(4):499-512. doi: 10.1016/j.coms.2018.06.010.
8
Comparison between open partial laryngectomy with tube-free tracheostomy and total laryngectomy for hypopharyngeal cancer with cartilage invasion.开放性部分喉切除术联合免管气管造口术与全喉切除术治疗侵犯软骨的下咽癌的比较
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9
Extreme long-term voice outcomes after concurrent chemoradiotherapy for advanced non-laryngeal head and neck cancer: Eight-year post-treatment analysis.晚期非喉头颈癌同步放化疗后的长期嗓音结局:治疗后八年分析
Clin Otolaryngol. 2018 Dec;43(6):1494-1499. doi: 10.1111/coa.13204. Epub 2018 Sep 6.
10
Anticancer therapy and lung injury: molecular mechanisms.抗癌治疗与肺损伤:分子机制。
Expert Rev Anticancer Ther. 2018 Oct;18(10):1041-1057. doi: 10.1080/14737140.2018.1500180. Epub 2018 Jul 23.