Kim Y S, Carp R I, Callahan S M, Wisniewski H M
New York State Office of Mental Retardation and Developmental Disabilities, Institute for Basic Research, Staten Island 10314.
Proc Soc Exp Biol Med. 1988 Oct;189(1):21-7. doi: 10.3181/00379727-189-42774.
In previous studies we found an increase in body weight during the preclinical phase of disease in certain scrapie strain-mouse strain combinations. The effect was augmented by injection into the hypothalamus. In the present study, we found an increase in food consumption (compared to the normal mouse brain injection group) for both the 139A and ME7 scrapie groups, although only the ME7 group showed an increase in body weight. In a scrapie strain-mouse strain combination that showed an increase in body weight, the adrenal gland was the only organ that showed a significant increase in weight. The titer of scrapie in the adrenals was comparatively low. Adrenalectomy prevented the increase in body weight in two strains of mice injected with the ME7 scrapie strain. The results suggest that scrapie-induced obesity depends on an effect of scrapie on the hypothalamic-pituitary-adrenal axis.
在先前的研究中，我们发现，在某些羊瘙痒病毒株与小鼠品系的组合中，疾病临床前期体重会增加。向下丘脑注射会增强这种效应。在本研究中，我们发现，139A和ME7羊瘙痒病组的食物消耗量均增加（与正常小鼠脑注射组相比），尽管只有ME7组体重增加。在一个体重增加的羊瘙痒病毒株与小鼠品系组合中，肾上腺是唯一体重显著增加的器官。肾上腺中羊瘙痒病的滴度相对较低。肾上腺切除术可防止注射ME7羊瘙痒病毒株的两个小鼠品系体重增加。结果表明，羊瘙痒病诱导的肥胖取决于羊瘙痒病对下丘脑 - 垂体 - 肾上腺轴的影响。
