2016 年 1 月至 2017 年 5 月，英格兰和威尔士注射吸毒者和无家可归者社区中 emm66 组 A 链球菌（GAS）爆发的全基因组测序。
Genomic sequencing of a national emm66 group A streptococci (GAS) outbreak among people who inject drugs and the homeless community in England and Wales, January 2016-May 2017.
机构信息
Bacteriology Reference Department, Public Health England, 61 Colindale Avenue, NW9 5EQ London, UK; European Programme for Public Health Microbiology Training (EUPHEM), European Centre for Disease Prevention and Control (ECDC), Gustav III:s boulevard 40, 169 73 Solna, Stockholm, Sweden.
United Kingdom Field Epidemiology Training Programme, Public Health England, 61 Colindale Avenue, NW9 5EQ London, UK; Field Epidemiology Services, National Infection Service, Public Health England, Wellington, Waterloo Rd, Lambeth, London SE1 8UG, London, UK.
出版信息
J Infect. 2019 Nov;79(5):435-443. doi: 10.1016/j.jinf.2019.08.009. Epub 2019 Aug 13.
An outbreak of an uncommon emm type (emm66.0) of group A streptococcus (GAS) occurred in England and Wales between January 2016 and May 2017, involving 52 individuals who were homeless or injecting drugs users. In order to investigate the outbreak, epidemiological and network analysis were performed; moreover 55 isolates (32 outbreak, 5 non-outbreak and 13 historical - 2005-2015) were tested with whole genome sequencing (WGS), antimicrobial resistance determination, Bayesian evolutionary analysis (BEAST). Forty one isolates (including 32 outbreak strains) belonged to a single emm66.0 clade (average SNP difference 6.6; range 0-16 SNPs) separate from the other isolates and two strains previously considered part of the outbreak (SNP average: 5876; range 93-8417 SNPs). Antibiotic resistance was not detected in the outbreak clone. No common source of infection was identified. WGS confirmed expansion of an emm66.0 clone in a hard-to-reach population and enabled refinement of the initial case definition.
2016 年 1 月至 2017 年 5 月期间，英国和威尔士爆发了一种不常见的 A 组链球菌（GAS）emm 型（emm66.0）疫情，涉及 52 名无家可归或注射毒品的患者。为了调查疫情，进行了流行病学和网络分析；此外，对 55 株分离株（32 株暴发株、5 株非暴发株和 13 株历史株-2005-2015 年）进行了全基因组测序（WGS）、抗菌药物耐药性测定、贝叶斯进化分析（BEAST）。41 株分离株（包括 32 株暴发株）属于一个单独的 emm66.0 分支（平均 SNP 差异 6.6；范围 0-16 SNP），与其他分离株和之前被认为是疫情一部分的两株分离株（SNP 平均值：5876；范围 93-8417 SNP）不同。在暴发株克隆中未检测到抗生素耐药性。未确定共同感染源。WGS 证实了 emm66.0 克隆在难以触及的人群中的扩展，并改进了最初的病例定义。
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