2018-2019 年美国侵袭性 A 组链球菌中由基因组群驱动的红霉素不敏感性和克林霉素不敏感性持续增加。
Continued Increase of Erythromycin Nonsusceptibility and Clindamycin Nonsusceptibility Among Invasive Group A Streptococci Driven by Genomic Clusters, United States, 2018-2019.
机构信息
Respiratory Diseases Branch, Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
出版信息
Clin Infect Dis. 2023 Feb 8;76(3):e1266-e1269. doi: 10.1093/cid/ciac468.
Abstract
We analyzed 9630 invasive GAS surveillance isolates in the USA. From 2015-2017 to 2018-2019, significant increases in erythromycin-nonsusceptibility (18% vs 25%) and clindamycin-nonsusceptibility (17% vs 24%) occurred, driven by rapid expansions of genomic subclones. Prevention and control of clustered infections appear key to containing antimicrobial resistance.
摘要
我们分析了美国 9630 株侵袭性酿脓链球菌监测分离株。从 2015-2017 年到 2018-2019 年，红霉素不敏感（18%比 25%）和克林霉素不敏感（17%比 24%）显著增加，这是由基因组亚克隆的快速扩张驱动的。聚集性感染的预防和控制似乎是控制抗菌药物耐药性的关键。
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