Shiiki S, Fuchimoto S, Orita K
First Department of Surgery, Okayama University Medical School, Japan.
Res Commun Chem Pathol Pharmacol. 1988 Sep;61(3):345-51.
We assessed the antiproliferative effects of natural human tumor necrosis factor alpha (nHuTNF-alpha) and natural interferon alpha and gamma (nHuIFN-alpha and -gamma), either alone or in combination, on human lung, colon, breast cancer, leukemia and lymphoma cell lines (PC10, RPMI4788, ZR-75-1, K562 and Daudi). PC10 and ZR-75-1 were minimal sensitive (30-50% inhibition) to nHuTNF-alpha. PC10 and RPMI4788 were sensitive to both nHuIFN-alpha and -gamma. K562 and Daudi were resistant to nHuTNF-alpha and also to nHuIFN-alpha and -gamma at the concentration tested. The combination treatment with nHuTNF-alpha and nHuIFN-alpha or -gamma showed the marked antitumor effects in four cell lines (PC10, RPMI4788, ZR-75-1 and Daudi). Though further investigations using fresh tumors or in vivo experiments need to be conducted, our results may have therapeutic implications.
我们评估了天然人肿瘤坏死因子α（nHuTNF-α）以及天然干扰素α和γ（nHuIFN-α和 -γ）单独或联合使用时，对人肺癌、结肠癌、乳腺癌、白血病和淋巴瘤细胞系（PC10、RPMI4788、ZR-75-1、K562和Daudi）的抗增殖作用。PC10和ZR-75-1对nHuTNF-α敏感性最低（抑制率为30 - 50%）。PC10和RPMI4788对nHuIFN-α和 -γ均敏感。在测试浓度下，K562和Daudi对nHuTNF-α以及nHuIFN-α和 -γ均耐药。nHuTNF-α与nHuIFN-α或 -γ联合治疗在四种细胞系（PC10、RPMI4788、ZR-75-1和Daudi）中显示出显著的抗肿瘤作用。尽管需要使用新鲜肿瘤进行进一步研究或开展体内实验，但我们的结果可能具有治疗意义。
