Department of Mechanical Engineering, Universidad Politécnica de Madrid, Madrid, Spain.
Department of Mechanical Engineering, School of Engineering, University of Birmingham, Birmingham, United Kingdom.
J Biomech. 2019 Sep 20;94:193-201. doi: 10.1016/j.jbiomech.2019.07.033. Epub 2019 Aug 7.
Aspiration thrombectomy is one of the most effective systems for blood clot removal and vessel recanalization. We present the results of a study involving the modelling and extraction of blood clots in the arteries of the human body using the following computer tools: Bond-Graph methodology for the fluid domain and Multi-Body Simulation for the mechanical domain. The modelling for the mechanical domain focuses on the clot and the distal end section of an aspiration device. Our final model considers an elastic characterization of the blood clot with progressive detachment from the vessel wall. We conclude that the results of such modelling could potentially improve the effectiveness of blood clot removal by reducing the risk of clot fragmentation. Such modelling could also potentially provide an adjunct technique in improving recanalization of arteries over a range of given parameters (mechanical properties of the vessel, mechanical properties of the blood clot, blood clot length, suction pressure, catheter - clot distance, catheter shape, catheter diameter and vessel occlusion).
抽吸血栓切除术是最有效的清除血栓和血管再通系统之一。我们展示了一项研究的结果，该研究使用以下计算机工具对人体动脉中的血栓进行建模和提取：用于流体域的键合图方法和用于机械域的多体仿真。机械域的建模侧重于血栓和抽吸装置的远端部分。我们的最终模型考虑了血液凝块的弹性特性，并逐渐从血管壁上分离。我们得出结论，通过降低血栓碎片的风险，这种建模的结果有可能提高血栓清除的效果。这种建模还有可能通过改善一系列给定参数（血管的机械性能、血栓的机械性能、血栓长度、抽吸压力、导管-血栓距离、导管形状、导管直径和血管闭塞）下的动脉再通提供一种辅助技术。
