Department of Medicine, McGill University Health Centre Research Institute, McGill University, Montreal, Quebec, Canada.
III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Kidney Int. 2019 Oct;96(4):850-861. doi: 10.1016/j.kint.2019.05.015. Epub 2019 May 31.
The podocyte is a key component of the glomerular filtration barrier. Podocyte dysfunction is central to the underlying pathophysiology of many common glomerular diseases, including diabetic nephropathy, glomerulonephritis and genetic forms of nephrotic syndrome. Collectively, these conditions affect millions of people worldwide, and account for the majority of kidney diseases requiring dialysis and transplantation. The 12th International Podocyte Conference was held in Montreal, Canada from May 30 to June 2, 2018. The primary aim of this conference was to bring together nephrologists, clinician scientists, basic scientists and their trainees from all over the world to present their research and to establish networks with the common goal of developing new therapies for glomerular diseases based on the latest advances in podocyte biology. This review briefly highlights recent advances made in understanding podocyte structure and metabolism, experimental systems in which to study podocytes and glomerular disease, disease mediators, genetic and immune origins of glomerulopathies, and the development of novel therapeutic agents to protect podocyte and glomerular injury.
足细胞是肾小球滤过屏障的关键组成部分。足细胞功能障碍是许多常见肾小球疾病（包括糖尿病肾病、肾小球肾炎和遗传性肾病综合征）潜在病理生理学的核心。这些疾病在全球范围内影响着数百万人，占需要透析和移植的肾脏疾病的大多数。第 12 届国际足细胞会议于 2018 年 5 月 30 日至 6 月 2 日在加拿大蒙特利尔举行。本次会议的主要目的是召集来自世界各地的肾脏病学家、临床科学家、基础科学家及其学员，展示他们的研究成果，并建立网络，共同目标是基于足细胞生物学的最新进展，为肾小球疾病开发新的治疗方法。本文简要介绍了近年来在理解足细胞结构和代谢、研究足细胞和肾小球疾病的实验系统、疾病介质、肾小球病的遗传和免疫起源以及新型治疗药物的开发以保护足细胞和肾小球损伤方面取得的进展。
