Department of Respiratory Medicine, Suzhou Municipal Hospital, Suzhou Hospital Affiliated Nanjing Medical University, Suzhou, Jiangsu, China.
Department of General Medicine, Suzhou Municipal Hospital, Suzhou Hospital Affiliated Nanjing Medical University, Suzhou, Jiangsu, China.
Mol Carcinog. 2019 Oct;58(10):1919-1924. doi: 10.1002/mc.23086. Epub 2019 Aug 16.
Lung cancer is among the most frequently occurring cancers and the leading cause of cancer-related deaths worldwide. Nonsmall cell lung cancer is accountable for 85% to 90% of all lung cancer cases and develops distant metastases with high mortality. In this work, we elucidated the role of activating transcription factor 1 (ATF1) in migration and invasion of lung cancer cells. We found that the migration and invasion were inhibited with ATF1 silencing in lung cancer cells. By contrast, ATF1 overexpression led to promotion in migration and invasion. The alteration in ATF1 expression induced a change in the epidermal growth factor receptor (EGFR) and matrix metalloproteinases (MMP)-2 expression level in the same tendency. Thus, we provided a potential new candidate for therapies against lung cancer, showing the possible mechanism underlying the invasion and migration of lung cancer cells.
肺癌是最常见的癌症之一，也是全球癌症相关死亡的主要原因。非小细胞肺癌占所有肺癌病例的 85%至 90%，并且具有高死亡率的远处转移。在这项工作中，我们阐明了激活转录因子 1（ATF1）在肺癌细胞迁移和侵袭中的作用。我们发现，肺癌细胞中 ATF1 的沉默抑制了迁移和侵袭。相比之下，ATF1 的过表达导致迁移和侵袭的促进。ATF1 表达的改变诱导表皮生长因子受体（EGFR）和基质金属蛋白酶（MMP）-2 的表达水平发生相同的变化。因此，我们为针对肺癌的治疗提供了一个潜在的新候选物，显示了肺癌细胞侵袭和迁移的潜在机制。
